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Thread: Leptin for Dummies post

  1. #1

    Leptin for Dummies post

    I saw this posted by Grizz over at MDA and am bringing it here. Perhaps a sticky, Colleen?


    Introduction to Leptin for newbees, many thanks Dr. Kruse for his help. This post will be referenced in the new Leptin Reset Index here:
    http://tinyurl.com/Dr-Kruse-References
    Please let me know if you see errors so I can correct them.

    “Here is the bottom line in as few words as possible. Humans are either sugar burners or they are fat burners as determined by diet. The High Carb – Low Fat Diet insures that we are sugar burners, and store fat. The High Carb diet also dulls the brain’s sensitivity to LEPTIN. The following skips all the scientific mumbo jumbo to explain a very complex & confusing subject for Dummies.

    Leptin For Dummies
    ================================================== =======
    * Leptin = Hormone that comes from fat and is sent to the brain & all other cells to control energy
    * Leptin is the MASTER Hormone that controls all other body hormones including insulin
    * Leptin is the feedback loop between fat cells & the brain and all systems that use energy.
    * Leptin Sensors in the brain are the “Gas Tank” that measures fat stores
    * Leptin HELPS tells the Brain when to eat, when to stop eating with the incretin hormones
    * Anything that uses Energy in the body is therefore tied to leptin status.
    * The more energy dependent the physiologic process the more coupled it is to proper leptin function.
    * Leptin allow the body to burn fat very efficiently even when sugar/carbs are plentiful
    * Leptin allows the brain to live through “Starvation Mode”
    * Leptin signaling can be blocked in the brain = High Leptin levels = Leptin Resistant = Starvation Mode/Obesity
    * Starvation Mode = body told to burn sugar, then eventually it causes osteoporosis and fatty muscles
    * Leptin sensors in the brain OK = Low leptin levels = Leptin receptor Sensitive = body is able burn fat well.
    * We can train our bodies to be a fat burner by a special diet to restore Leptin sensitivity
    * IF the leptin receptor is permanently damaged we can train our brain to re read leptin signal with the Leptin Rx.
    * Blood testing can measure Leptin levels, but they are rather useless clinically.
    * The Liver makes energy for use between meals and is our metabolic engine, the thyroid is the gas pedal, and leptin is the computer who modulates control over both using hormone signals.

    Characteristics of the Sugar Burner = High levels of leptin = Brain Leptin Resistant (LR)
    ================================================== =======
    - – A lifetime of eating high PUFA containing foods, High Carb foods, a life of elevated cortisol with poor sleep damages the Leptin Receptors in the brain
    * Brain receptors that are blocked, do not detect Leptin well any longer, and in some cases may be damaged
    * When the Leptin receptor is blocked the brain sees the body as in “Starvation Mode” to store even more fat with every meal.
    * In obese, you are hungry even when overweight, urges to snack, no signals to stop eating when full
    * In anorexia no hunger, thyroid shut down and you consume your own bodies protein, bone, and fat.
    * Dieting wont work when LR; exercise is highly inflammatory when your are LR and wont help because you still won’t burn fat well at muscle level until you become LS.
    * Blood sugar can become out of control, leading to diabetes: Intracellular loss of Magnesium is the first step in LR.
    * Thyroid Gland is no longer under control of brain in LR, and basically not functioning well regardless of lab findings
    * Thyroid shuts down, preventing muscles from burning fat
    *A nation of Obese People are walking around in “Starvation Mode” because their brain is blind to their fat stores.
    * Liver gets overloaded with energy, becomes fatty and sluggish causing our Ferrari’s engine to become inefficient
    * Belly fat accumulates as LR continues for the obese and waistline increases. Anorexics waste away and die.

    Characteristics of the Fat Burner = Low levels of Leptin = Brain Leptin Sensitive (LS)
    ================================================== ========
    * Satisfied after eating, can even skip meals without getting hungry, no desire for snacks,
    * Body burns fat instead of sugar
    - – Exercise & Dieting results in burning stored energy, then fat cells and NOT muscle & bone
    * Blood sugar under tight control because your liver will be optimized once again to run like a Ferrari engine
    * Thyroid functioning normally because leptin will allow the brain to control its gas pedal once again.
    * Body no longer in “Starvation Mode,” healthy weight controlled for the obese or the anorexic
    *The reset can use Low Carb Diet high protein or high fat diet timed correctly to reset how our neurons work once again and allow us to once again become effective fat burners.
    - – Hormone levels are properly controlled and normal levels will eventually return as leptin function normalizes
    - – You will be able to eventually eat anything you want & not gain weight once your brain is retrained.

    So bottom line, people who can’t lose weight or who have diabetes- can blame it on their epigenetic switches that are set to partition calories differently than a normal persons metabolism because the are likely to be Leptin Resistant. No amount of dieting will work until Leptin Receptors get trained to function properly again. This normally takes 6 to 8 weeks of the “Leptin Reset” protocol which use adaptive neuroplasticity to allow our brain to once again be sensitive to our fat stores and restore us to energy efficient again. The LEPTIN RESET IS RETRAINING LEPTIN NEURONS TO RESIGNAL TO APPROPRIATE SIGNS USING TIMING OF THE MEALS AND AND FUELS AND GUT SENSATIONS TO REORGANIZE HYPOTHALAMIC FUNCTION IN THE HYPOCRETIN NEURONS. The more systemic inflammation one has the longer the reset can take. This means the timing of return of the leptin reset is dependent upon variables in each one of us. Patience is the key.

    For more details, refer to Dr. Kruse’s Blog Index to Articles & message threads on Leptin here:
    http://tinyurl.com/Dr-Kruse-References

    Grizz
    Just read Weight Loss Apocalypse which gave me new resolve.
    Currently getting back to the ticker weight.

  2. #2
    Formerly Squishy Steveo's Avatar
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    AWESOME!!! Maybe I shouldnt be posting here... but this is really useful! Thanks!

    I hope they sticky it!
    R1-R4 round -182lbs
    R5/P2 hcg injections

    "I call HCG a gateway drug to Paleo. LOL" - Grammy1952 Nov 2012

  3. #3
    Senior Member Rhibert's Avatar
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    This TOTALLY needs to be a sticky... besides the fact that this guy's link has ALL the other links in it too!
    3/28/11 R1P2D1 = 231.0
    5/06/11 R1P2D40 = 202.2 LDW
    R1 loss = 28.8 lbs

    6/12/11 R2P2D1 = 208.2 (5lb load)
    7/14/11 R2P2D33 = 184.4 LDW
    R2 loss = 23.8 lbs

    8/29/11 R3P2D1 = 192.8 (6.6lb load)
    10/4/11 R3P2D37 = 171.4 LDW
    R3 loss = 21.4 lbs

    1/30/12 R4P2D1 = 193.6 (9 lb load)
    3/08/12 R4P2D36 = 168.2 LDW
    R4 loss = 25.4 lbs

    Total (net) loss in 4 rounds = 62.8 LBS!!

    Eventual Goal: 153.6 lbs, BMI 24.98, NORMAL!


  4. #4
    Senior Member MiniMe's Avatar
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    What is the physiological reason why you are recommending so high amounts of protein (on breakfast)?

    Two major reasons. The first has to do with the gut incretin hormones. When someone is LR they not only have a metabolic derangement at the brain level but also at the muscle and liver levels. You can read about both in my first two leptin posts back from June of 2011. When one eats a high protein and fat breakfast it allows proper signaling to be reestablished between the small intestine, liver and the brain. We actually have circadian rythmns in for sleep and food in our gut organs and our brains. The major appetite incretin is gherlin. The satiety incretin is NYY Prtein and fat in the AM increase satiety very fast. The goal is to eliminate cravings and improve satiety. Cravings are controlled by NPY in the brain and carbs restriction and satiety by NYY and use of high dose protein and fat.

    The second reason is is when you eat higher protein it is thermogenic and stimulates the thyroid and uncoupling proteins to begin to function again. Kinda like priming the pump. But the real reason is one needs protein synthesis to stimulate muscle growth to eventually burn fat and not sugar. This is how the weight loss comes. For the anorexic they add muscle bulk with the protein and carb eating. The more muscles that are active the more fat can be burned and the more carbs can be tolerated in the diet and by the brain. Those are the physiologic reasons.

    quoted from http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  5. #5
    Senior Member MiniMe's Avatar
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    Why no nightshades on the reset?

    If you read about night shades they cause issues similar to a leaky gut. So if you re read my VAP= Leaky gut post you will see that I use the VAP as a proxy to see if the gut is leaky. Most people doing a reset all have really bad HDL levels. This means the liver is not as good a filter as it could be. IE the gut is leaky to more inflammation than it need be. This is also why the HS CRP is higher. It tells us that the plasma is more oxidative to our systems. And this fosters leptin resistance. Therefore, during the reset we want to do everything possible to eliminate inflammation and that is why you should avoid the nightshades. And if you happen to get a lipid panel on your reset……and as a female your HDL is above 60, or as a male above 70, then I say you can eat nightshades on the reset. In my six years of doing this I have not seen a LR person who fit that bill as yet.

    quoted from http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  6. #6
    Senior Member MiniMe's Avatar
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    Why is it okay to skip lunch or dinner but not breakfast?

    In the AM humans have diurnal cortisol pattern. It’s high in the morning and lowest at night. The evolutionary biologic function is to one, wake up the brain from sleep and two to get us up to feed. So when cortisol is highest we should be waking up eating. When cortisol is lowest we should be eating less and getting ready to sleep. It’s lowest from 6 to 9 pm. When you eat late at night you are destroying the normal diurnal rhythms of how cortisol and leptin are designed to work. Do this long enough you screw up the diurnal clocks in the liver and muscle too. Not just the brain. And that is how LR insidiously takes over. Neolithic foods are but one part of e obesity story. Reading Taubes, Guyenet, Dr. Lustig or Dr Davis you’d be led to believe “some theory” of obesity. Mine is a pretty simple top down look. Everything begins in the brain. Macronutrients are partioned based upon energy needs and by diurnal releases of hormones that ironically the brain also releases. Everything is dictated by the brain. This is why leptin is King of the Hill.

    quoted from http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  7. #7
    Senior Member MiniMe's Avatar
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    What is the reasoning for the perceived increase in body heat?

    the reason for the body heat is two fold. First, is since we are priming the gut with a huge protein load in the AM you get a thermogenic effect of protein on mitochondria. This signal affects the incretin signaling to the brain to affect satiety and appetite. Once this is established the brain begins to send metabolic signals to the muscles UCP to burn calories as heat as well. This however requires thyroid hormone to become active as well. This is the second reason you will feel the heat so to speak. People with Hashimoto’s of bad thyroid function (low T3) will struggle with this for a while and may need a doctor to help jump start it. Eventually it can be repaired and this step is critical to lowering the LDL that will occur in some who eat a paleo diet who have poor T3. Remember the conversion of LDL cholesterol to the steroids the brain uses for signaling requires T3 and vitamin A. Once someone is LS for a long period of time 12-24 months you will notice the heat go away and your body temp will actually lower with time. This is a long term sign that LS has set in. You will also note that you can eat anything you want without gaining weight. There are many LS people who experience this and others wonder aloud how they can eat whatever they want and not gain weight. This is how it happens.

    from http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  8. #8
    Senior Member MiniMe's Avatar
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    About loose skin and stretch marks and how to deal with them.

    I responded to this in the MDA monster thread around page 83 on my iPad. Here is the response. Some one asked about loose skin post weight loss too……here are my thoughts.
after my patients lose their weight we use a few things to tighten skin over about 12 months…..high dose Vit K2 and teprenone (Oral and topical), caprylic acid (oral and topical) and high dose dietary palm and coconut oil. It does amazing things to adipocytes and the skin once the weight is gone.
I also add a couple of high dose supplements too….NAC and R-lipoic acid and resveratrol. This is not for a leptin reset…….this is when you are looking to lose the last twenty pounds after your weight loss.
If there is a lot of cellulite marks I also ask patients to consider high dose super curcumin as well.

    Skin issues mean a few things to me…..first I think grains……totally eliminate all. Second Vitamin D has to be optimal For me that is above 70 and with correct Vitamin K2 and D3 levels. Third issue is a serious lack of good fats in the skin…..by this i am thinking the O6/3 ratio. I correct this by using caprylic acid (found in coconut oil and K2 foods). I eat a ton of coconut oil and I use coconut oil and olive oil directly on my skin. I also use epsom salts baths to get my sulfur levels up. My blog post today (October 5, 2011) will tell you why.


    http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  9. #9
    HCG Wise Woman derocherl's Avatar
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    This thread is great, thanks! Can someone answer this question or point me to the answer, please? What is the reason behind just 2 or 3 meals each day? I'm trying to understand the logic, since I've been indoctrinated about eating six smaller meals to keep metabolism revved. Thank you.
    Laura

  10. #10
    Senior Member MiniMe's Avatar
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    Quote Originally Posted by derocherl View Post
    This thread is great, thanks! Can someone answer this question or point me to the answer, please? What is the reason behind just 2 or 3 meals each day? I'm trying to understand the logic, since I've been indoctrinated about eating six smaller meals to keep metabolism revved. Thank you.
    My understanding is that this is not the way humans have evolved, and our hormones and receptors were not meant to be constantly fed. Hunger is a very important chemical and biological state – it is normal and natural. If you are constantly feeding your body, your hormones and brain signaling kind of become immune to each other. Many small meals a day and snacking is also very stressful on the liver. The liver plays a critical role in the regulation and metabolism of fat – so you don’t want to be constantly stressing it with food.
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  11. #11
    Senior Member MiniMe's Avatar
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    WHEN TO START EXERCISING AND WHAT TYPE OF EXERCISE TO DO

    First you must be leptin-sensitive:

    Do you notice you sweat more and have less muscle fatigue when you exercise now?
    Have your carb cravings gone away?
    Is your hunger under control now?
    And are you waking up more refreshed?



    When these questions are all yes, then I push the button and tell them to start exercising more with intensity and duration first using weights but never using aerobics. The reason for weight lifting first, is that it generates less ROS in the muscle at the mitochondrial level, and more importantly that it stimulates the release of growth hormone to fire up muscle activity via the neuroendocrine system. It also more quickly reestablishes the Leptin sensitivity of the furnaces that our muscles contain to burn the fat we want to get rid of. As they improve, more weight comes off and the exercise plan increases. So far this plan has not failed me because it is not based upon my opinion. It is based upon our biochemistry that is 2 million years old!

    Most of my neurosurgical patients get this treatment before I will operate on them because outcomes are better when the patient is metabolically fit for recovery. If you are a patient who is Leptin resistant, and work too hard too quickly with exercise as you drop weight, the risk is generating too much ROS and depleting your stem cell supply. (Levee 17) The short term effect will be weight loss and a good result, but the long term effect may be faster aging and decrease longevity!

    http://jackkruse.com/
    ROUND 1
    Preload:157
    LIW = 135.4
    Total VLCD Days: 62
    Total from preload: -21.6


    ROUND 2
    Preload: 146.8
    VLCD40: 129.8: -17

  12. #12
    Member HarveysMom's Avatar
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    I don't know if anyone is still monitoring this thread, but I hope they are because I have a question. I keep hearing about the recommended "Big *** Breakfast," and comments about eating a "huge amount of protein" for breakfast. But Dr. Kruse said the following about breakfast: "Make sure that breakfast has little to no carbs (less than 50 grams), and has a lot of protein and fat. I use as a general rule 50-75 grams of protein with most patients."

    Now, 75 grams of protein is less than 2.5 ounces, or about 4 small bites. I don't know about you, but 4 small bites is NOT what I would call a "huge" breakfast. In fact, it is even less than P&I protocol prescribes for weight loss with the hCG helping to eliminate hunger.

    Am I missing something here?

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