This is a commonly asked question by patients wanting to know how long Hcg remains in the bloodstream, and how long before it is out. To answer this question, let’s first clarify some pharmacokinetic information on hCG.
The Half Life of HCG Hormone
The Hcg hormone has a half life of 23-37 hours, with it’s time to peak action is 6 hours, and the duration of action being 36 hours. The half life of a medication is the amount of time it takes for 50% of it to be cleared from your system. For hCG the given range is usually between 23-37 hours.
We typically will use 36 hours for our calculations to make the math a little simpler and to lean on the conservative side with these estimates.
So if 50% of the hCG is cleared in 36 hours ( one day and a half) the hCG dose decreases in your system by half over that time. Attached is a table showing estimates for hCG levels over 10 days starting from the most common weight loss dose ranges.
General recommendations based on the hCG half life include guidelines for coming off hCG, where patients are instructed to continue the Hcg diet for the first couple of days of stopping the medication. This is because the half-life is on the longer side and so the medication does persist for several days after stopping. After a week to 10 days the medication reaches very low levels. Beyond 10 days the levels would be close to zero.
There are two effects which can persist for a short period for some women coming off of hCG. First is the drop in hormones can sometimes trigger a similar scenario to postpartum hair loss, which many women experience in the months following a pregnancy. This is experienced as minor shedding which will typically grow back in a hair cycle of several months.
This side effect is rare when the hCG is dosed correctly. Some clinics use a standard high dose of 200 IU for all patients and this can then increase the occurrence of hair shedding when stopping the hCG (this does not happen during the Hcg Diet protocol, that is usually from excessively low protein/calories) (VLCD.)
The other is that the next menstrual cycle coming off the hCG may be irregular due to the effect of the hCG (and so progesterone) on the uterine lining (making it thicker). The next cycle may be earlier and heavier, but also occasionally later. This persisting effect is very rare and does not last more than the first menstrual cycle coming off the hCG.
In summary, to calculate hCG clearance the starting dose must be known and it is then reduced by half every day and a half, with levels approaching zero by the 10th day from stopping.
About the Author: Dr. Nishant Rao is the medical director of a nationwide, telemedicine weight loss organization, Diet Doc. During the past 9 years in this role,he has worked with a team of physicians providing weight loss to people using hCG. Dr. Rao is sought after as the leading doctor expert in hCG and weight loss along with the clinical approval process he recommended doctors employ when prescribing hCG.Dr. Rao has successfully formulated over a dozen, highly sought after medications during his tenure. His expert advice and care are used as a platform/model to help train other physicians so they may utilize safe and acceptable standards of care when approving individuals to receive hCG.